:root {
    --ui-bg: #f6f8fb;
    --ui-surface: #ffffff;
    --ui-border: #d7e0ea;
    --ui-text: #102238;
    --ui-muted: #4d6078;
    --ui-accent: #0f6eb8;
    --ui-accent-soft: #e8f4ff;
  }
  main.shell { padding-top: 14px; padding-bottom: 20px; }
  .hero {
    padding: 16px 18px;
    margin-bottom: 10px;
    background: linear-gradient(120deg, #f0f7ff 0%, #f8fbff 45%, #edf5f2 100%);
    border: 1px solid var(--ui-border);
    border-radius: 12px;
  }
  .hero h1 { margin: 0 0 4px 0; font-size: 24px; }
  .hero p { margin: 0; color: var(--ui-muted); font-size: 13px; }
  .card {
    padding: 12px;
    margin-bottom: 10px;
    background: var(--ui-surface);
    border: 1px solid var(--ui-border);
    border-radius: 12px;
    box-shadow: 0 2px 8px rgba(8, 30, 66, 0.04);
  }
  .layout { display: grid; grid-template-columns: minmax(0, 1fr) 300px; gap: 12px; align-items: start; }
  .panel {
    padding: 10px;
    border: 1px solid var(--ui-border);
    border-radius: 10px;
    background: var(--ui-bg);
    margin-bottom: 8px;
  }
  .panel h3 {
    margin: 0 0 8px 0;
    font-size: 14px;
    color: #0e2947;
    display: flex;
    align-items: center;
    gap: 8px;
  }
  .grid-2 { display: grid; grid-template-columns: repeat(2, minmax(0, 1fr)); gap: 8px; }
  .grid-3 { display: grid; grid-template-columns: repeat(3, minmax(0, 1fr)); gap: 8px; }
  .grid-4 { display: grid; grid-template-columns: repeat(4, minmax(0, 1fr)); gap: 8px; }
  .form-group { margin-bottom: 8px; }
  .form-label {
    margin-bottom: 5px;
    font-weight: 600;
    display: flex;
    align-items: center;
    gap: 6px;
    color: #21384f;
    font-size: 13px;
  }
  .form-control {
    width: 100%;
    border: 1px solid #c4d2e2;
    border-radius: 8px;
    padding: 7px 9px;
    font-size: 13px;
    background: #fff;
    color: var(--ui-text);
  }
  .form-control:focus {
    outline: none;
    border-color: var(--ui-accent);
    box-shadow: 0 0 0 2px rgba(15, 110, 184, 0.15);
  }
  textarea.form-control { min-height: 112px; font-family: ui-monospace, SFMono-Regular, Menlo, Monaco, Consolas, "Liberation Mono", "Courier New", monospace; }
  .small-note { font-size: 12px; color: var(--ui-muted); margin-top: 4px; }
  .toolbar { display: flex; gap: 8px; flex-wrap: wrap; align-items: center; }
  .toolbar-center { justify-content: center; }
  .status {
    padding: 8px 10px;
    border-radius: 8px;
    margin-top: 8px;
    background: #f8fafc;
    border: 1px solid #dde5ef;
    font-size: 12px;
    color: #29435c;
  }
  .status.success { background: #f0fdf4; border-color: #bbf7d0; color: #166534; }
  .status.error { background: #fef2f2; border-color: #fecaca; color: #991b1b; }
  .status-fixed {
    min-height: 40px;
    display: flex;
    align-items: center;
  }
  .chip {
    display: inline-block;
    padding: 2px 8px;
    border-radius: 999px;
    font-size: 11px;
    background: var(--ui-accent-soft);
    color: var(--ui-accent);
    border: 1px solid #c6ddf5;
  }
  .hint-btn {
    width: 20px;
    height: 20px;
    position: relative;
    display: inline-flex;
    align-items: center;
    justify-content: center;
    border-radius: 50%;
    border: 1px solid #9fb2c8;
    background: #eef3f8;
    color: #37526e;
    font-size: 12px;
    cursor: pointer;
    user-select: none;
    flex-shrink: 0;
    padding: 0;
    line-height: 1;
  }
  .hint-btn::after {
    content: attr(data-tip);
    position: absolute;
    left: 50%;
    top: calc(100% + 8px);
    transform: translate(-50%, 6px);
    min-width: 220px;
    max-width: 320px;
    padding: 8px 10px;
    border-radius: 8px;
    border: 1px solid #bfd1e4;
    background: #ffffff;
    color: #20384f;
    font-size: 12px;
    font-weight: 500;
    text-align: left;
    box-shadow: 0 8px 20px rgba(12, 31, 55, 0.12);
    opacity: 0;
    pointer-events: none;
    transition: opacity 0.12s ease, transform 0.12s ease;
    z-index: 16;
  }
  .hint-btn:hover::after,
  .hint-btn:focus-visible::after,
  .hint-btn.is-open::after {
    opacity: 1;
    transform: translate(-50%, 0);
  }
  .hint-btn:focus-visible {
    outline: 2px solid #6aa5d4;
    outline-offset: 1px;
  }
  .summary-kv {
    display: grid;
    grid-template-columns: 1fr auto;
    gap: 4px 8px;
    font-size: 12px;
  }
  .summary-kv .k { color: #4f6279; }
  .summary-kv .v { color: #17304c; font-weight: 600; }
  details.panel > summary {
    cursor: pointer;
    list-style: none;
    font-weight: 600;
    font-size: 14px;
    color: #173856;
    margin: -2px 0 8px 0;
  }
  details.panel > summary::-webkit-details-marker { display: none; }
  .table-wrap { overflow-x: auto; }
  table.result-table { width: 100%; border-collapse: collapse; min-width: 940px; font-size: 12px; }
  table.result-table th, table.result-table td { border-bottom: 1px solid #e3eaf2; padding: 7px 6px; text-align: left; }
  table.result-table th { background: #f6f9fc; color: #203a56; position: sticky; top: 0; }
  .kv-grid { display: grid; grid-template-columns: 180px 1fr; gap: 5px 10px; }
  .kv-k { font-weight: 600; color: #2f4965; font-size: 12px; }
  .kv-v { color: #102238; word-break: break-word; font-size: 12px; }
  .mini-bars { display: grid; gap: 7px; margin-top: 8px; }
  .mini-bar { display: grid; grid-template-columns: 100px 1fr 48px; gap: 8px; align-items: center; }
  .mini-bar-label { font-size: 12px; color: #334155; }
  .mini-bar-track { height: 9px; border-radius: 999px; background: #e2e8f0; overflow: hidden; }
  .mini-bar-fill { height: 100%; background: linear-gradient(90deg, #1d4ed8, #0ea5e9); }
  .mini-bar-count { font-size: 12px; color: #0f172a; text-align: right; }
  .sample-pill {
    display: inline-flex;
    align-items: center;
    border: 1px solid #d8e3ef;
    background: #f7fbff;
    color: #254564;
    border-radius: 999px;
    padding: 2px 10px;
    font-size: 12px;
    user-select: none;
    pointer-events: none;
    margin-left: 8px;
  }
  .checkbox-row {
    display: flex;
    align-items: flex-start;
    gap: 8px;
    font-weight: 500;
    color: #243f5a;
    font-size: 13px;
  }
  .checkbox-row input[type="checkbox"] {
    margin-top: 2px;
    width: 15px;
    height: 15px;
    flex-shrink: 0;
  }
  .advanced-oligo-grid {
    display: grid;
    grid-template-columns: minmax(240px, 1.2fr) minmax(200px, 1fr) minmax(220px, 1fr);
    gap: 8px;
    align-items: end;
    margin-top: 8px;
  }
  .advanced-toggle {
    display: flex;
    align-items: center;
    gap: 8px;
    min-height: 38px;
    padding: 7px 9px;
    border: 1px solid #d3deea;
    border-radius: 8px;
    background: #fff;
    font-weight: 500;
    color: #243f5a;
    font-size: 13px;
  }
  .advanced-toggle input[type="checkbox"] {
    width: 15px;
    height: 15px;
    margin: 0;
    flex-shrink: 0;
  }
  .advanced-toggle span {
    flex: 1;
    min-width: 0;
    line-height: 1.3;
  }
  .advanced-toggle .hint-btn {
    margin-left: auto;
  }
  .advanced-window-grid {
    display: grid;
    grid-template-columns: repeat(4, minmax(0, 1fr));
    gap: 8px;
    margin-top: 4px;
  }
  .input-subpanel {
    display: none;
  }
  .input-subpanel.active {
    display: block;
  }
  .gene-set-resolve-row {
    display: grid;
    grid-template-columns: minmax(0, 1fr) auto auto;
    gap: 8px;
    align-items: center;
  }
  .gene-set-meta-row {
    display: flex;
    align-items: center;
    gap: 8px;
    flex-wrap: wrap;
    margin-bottom: 6px;
  }
  .gene-set-workspace {
    display: grid;
    grid-template-columns: minmax(0, 1.35fr) minmax(260px, 0.65fr);
    gap: 10px;
    align-items: stretch;
  }
  .gene-set-list-wrap {
    border: 1px solid #dbe6f1;
    border-radius: 8px;
    background: #fff;
    padding: 6px;
    min-height: 206px;
    display: flex;
    flex-direction: column;
  }
  .gene-set-target-wrap {
    border: 1px solid #dbe6f1;
    border-radius: 8px;
    background: #fff;
    padding: 8px;
    min-height: 206px;
    display: flex;
    flex-direction: column;
  }
  .gene-set-target-wrap textarea.form-control { min-height: 160px; flex: 1; }
  .legacy-search-panel {
    margin-top: 8px;
    border: 1px solid #dbe6f1;
    border-radius: 8px;
    background: #f9fcff;
    padding: 8px;
    display: none;
  }
  .legacy-search-panel.active {
    display: block;
  }
  .legacy-search-toolbar {
    display: grid;
    grid-template-columns: minmax(0, 1fr) auto;
    gap: 8px;
    align-items: center;
  }
  .legacy-search-status {
    margin-top: 6px;
    font-size: 12px;
    color: #3f5d79;
  }
  .legacy-search-table-wrap {
    margin-top: 6px;
    max-height: 180px;
    overflow: auto;
    border: 1px solid #dbe6f1;
    border-radius: 8px;
    background: #fff;
  }
  .legacy-search-table {
    min-width: 0 !important;
    width: 100%;
    table-layout: fixed;
    font-size: 11px;
  }
  .legacy-search-table th,
  .legacy-search-table td {
    padding: 5px 4px !important;
    white-space: nowrap;
    overflow: hidden;
    text-overflow: ellipsis;
  }
  #gene-set-candidate-wrap {
    flex: 1;
    overflow: auto;
  }
  .gene-set-list-head {
    display: none;
  }
  .select-all-toggle {
    display: inline-flex;
    align-items: center;
    gap: 6px;
    padding: 4px 9px;
    border-radius: 999px;
    border: 1px solid #bfd1e4;
    background: #f3f8fd;
    color: #1f3f5f;
    font-size: 12px;
    font-weight: 600;
    cursor: pointer;
  }
  .select-all-toggle.compact {
    border: none;
    background: transparent;
    padding: 0;
    margin: 0;
    gap: 0;
    justify-content: center;
  }
  .select-all-toggle:hover {
    background: #e9f3fc;
    border-color: #9cb9d6;
  }
  .select-all-toggle input[type="checkbox"] {
    width: 14px;
    height: 14px;
    margin: 0;
    accent-color: var(--ui-accent);
  }
  .select-all-toggle input[type="checkbox"]:disabled {
    cursor: not-allowed;
    opacity: 0.6;
  }
  .resolved-table {
    min-width: 0 !important;
    width: 100%;
    table-layout: fixed;
    font-size: 11px;
  }
  .resolved-table th,
  .resolved-table td {
    padding: 5px 4px !important;
    white-space: nowrap;
    overflow: hidden;
    text-overflow: ellipsis;
  }
  .resolved-locus {
    font-size: 12px;
    color: #3f5d79;
  }
  .ext-link {
    color: #0f5f9a;
    text-decoration: none;
    border-bottom: 1px dashed #9fc6e3;
  }
  .ext-link:hover {
    color: #0b4f82;
    border-bottom-color: #0b4f82;
  }
  .result-actions {
    display: flex;
    gap: 8px;
    flex-wrap: wrap;
    align-items: center;
  }
  .output-head {
    display: flex;
    gap: 8px;
    align-items: center;
    flex-wrap: wrap;
    margin-bottom: 8px;
  }
  .card-title {
    margin: 0 0 8px 0;
    font-size: 18px;
  }
  .output-layout {
    display: grid;
    grid-template-columns: minmax(0, 0.95fr) minmax(0, 1.05fr);
    gap: 8px;
    align-items: stretch;
  }
  .output-layout > .output-panel {
    display: flex;
    flex-direction: column;
  }
  .output-panel {
    border: 1px solid #d9e3ee;
    border-radius: 10px;
    background: #fbfdff;
    padding: 7px;
  }
  .output-panel h3 {
    margin: 0 0 8px 0;
    font-size: 13px;
    color: #1e3851;
    display: flex;
    align-items: center;
    gap: 8px;
  }
  .insight-grid {
    display: grid;
    grid-template-columns: minmax(0, 0.95fr) minmax(0, 1.05fr);
    gap: 8px;
    margin-top: 8px;
  }
  .all-copy-insight-grid {
    grid-template-columns: minmax(0, 1fr) minmax(0, 3fr);
  }
  .insight-block {
    border: 1px solid #e0e7ef;
    border-radius: 8px;
    background: #fff;
    padding: 8px;
    min-width: 0;
  }
    table.result-table.insight-table {
      min-width: 0;
      width: 100%;
      table-layout: fixed;
      font-size: 12px;
    }
  .insight-title {
    margin: 0 0 6px 0;
    font-size: 12px;
    font-weight: 600;
    color: #2f4965;
  }
  .bokeh-wrap {
    border: 1px solid #e0e7ef;
    border-radius: 8px;
    background: #fff;
    min-height: 150px;
    padding: 4px;
  }
  .gtv-header {
    display: flex;
    align-items: flex-start;
    gap: 10px;
    margin-bottom: 6px;
  }
  .gtv-header h3 {
    margin: 0;
    white-space: nowrap;
  }
  .gtv-meta {
    display: flex;
    align-items: center;
    gap: 8px;
    flex-wrap: wrap;
    margin-left: auto;
  }
  .gtv-chip {
    display: inline-flex;
    align-items: center;
    gap: 6px;
    border: 1px solid #d6e1ed;
    border-radius: 999px;
    background: #f8fbff;
    color: #2b4863;
    font-size: 11px;
    padding: 3px 9px;
  }
  .gtv-swatch {
    width: 12px;
    height: 8px;
    border-radius: 2px;
    display: inline-block;
  }
  .gtv-note {
    font-size: 12px;
    color: #435b73;
    margin-left: auto;
  }
  .guide-list {
    margin-top: 6px;
    border: 1px solid #e0e7ef;
    border-radius: 8px;
    background: #fff;
    flex: 1;
    min-height: 0;
    max-height: 510px;
    overflow: auto;
  }
  .guide-head {
    display: grid;
    grid-template-columns: 74px minmax(0, 1fr) 60px 68px 66px 56px;
    gap: 6px;
    align-items: center;
    padding: 5px 8px;
    border: 1px solid #e0e7ef;
    border-radius: 8px;
    background: #f3f7fc;
    font-size: 12px;
    font-weight: 600;
    color: #36536f;
    margin-top: 4px;
  }
  .guide-head > div {
    text-align: left;
  }
  .guide-head > div:nth-child(n+3) {
    text-align: center;
    justify-self: stretch;
  }
  .guide-row {
    display: grid;
    grid-template-columns: 74px minmax(0, 1fr) 60px 68px 66px 56px;
    gap: 6px;
    align-items: center;
    padding: 6px 8px;
    border-bottom: 1px solid #edf2f7;
    cursor: pointer;
    font-size: 12px;
  }
  .guide-row > div:nth-child(n+3) {
    text-align: center;
    justify-self: stretch;
  }
  .guide-row:hover { background: #f3f8ff; }
  .guide-row.active { background: #e8f2ff; }
  .guide-id {
    color: #1b3d62;
    font-weight: 500;
    font-size: 12px;
  }
  .guide-seq {
    font-family: ui-monospace, SFMono-Regular, Menlo, Monaco, Consolas, "Liberation Mono", "Courier New", monospace;
    font-size: 12px;
    white-space: nowrap;
    overflow: hidden;
    text-overflow: ellipsis;
  }
  .guide-score {
    text-align: center;
    color: #1e3a56;
    font-weight: 500;
    font-size: 12px;
  }
  .guide-on-target {
    text-align: center;
    color: #1e3a56;
    font-weight: 500;
    font-size: 12px;
  }
  .guide-region {
    color: #405a73;
    font-size: 12px;
    text-align: center;
    white-space: nowrap;
    overflow: hidden;
    text-overflow: ellipsis;
  }
  .guide-gc {
    text-align: center;
    color: #3f5f79;
    font-weight: 500;
    font-size: 12px;
  }
  .warn-run {
    background: #fee2e2;
    color: #b91c1c;
    padding: 0 1px;
    border-radius: 2px;
  }
  .cut-mark {
    color: #0f172a;
    font-weight: 700;
    padding: 0 1px;
  }
  .mismatch-base {
    background: #ffe4e6;
    color: #be123c;
    border-radius: 2px;
    padding: 0 1px;
    font-weight: 700;
  }
  .detail-section {
    border: 1px solid #e0e7ef;
    border-radius: 8px;
    background: #fff;
    padding: 8px;
    margin-bottom: 8px;
  }
  .output-layout > .output-panel .detail-section:last-child {
    margin-bottom: 0;
  }
  .detail-pairs {
    display: grid;
    grid-template-columns: 1fr 1fr;
    margin-top: 8px;
  }
  .detail-pair-col {
    padding: 2px 10px;
  }
  .detail-pair-col + .detail-pair-col {
    border-left: 1px solid #dbe6f2;
  }
  .detail-pair-item {
    display: grid;
    grid-template-columns: 118px 1fr;
    gap: 6px;
    margin-bottom: 4px;
  }
  .detail-pair-k {
    font-size: 12px;
    font-weight: 600;
    color: #34506a;
  }
  .detail-pair-v {
    font-size: 12px;
    color: #102238;
  }
  .detail-seq {
    font-family: ui-monospace, SFMono-Regular, Menlo, Monaco, Consolas, "Liberation Mono", "Courier New", monospace;
    font-size: 13px;
    line-height: 1.5;
    word-break: break-all;
  }
  .detail-gene-block {
    margin-bottom: 8px;
    padding: 6px 8px;
    border: 1px dashed #d7e4f2;
    border-radius: 8px;
    background: #f8fbff;
  }
  .detail-gene-item {
    display: grid;
    grid-template-columns: 118px 1fr;
    gap: 6px;
    margin-bottom: 4px;
  }
  .detail-gene-item:last-child {
    margin-bottom: 0;
  }
  .detail-gene-v {
    font-size: 12px;
    color: #102238;
    word-break: break-all;
  }
  .offtarget-mini {
    max-height: 300px;
    overflow: auto;
    border: 1px solid #e6edf5;
    border-radius: 8px;
  }
  .offtarget-mini .result-table {
    min-width: 760px;
    width: max-content;
    table-layout: auto;
    font-size: 11px;
  }
  .offtarget-mini .result-table th,
  .offtarget-mini .result-table td {
    padding: 5px 4px;
    text-align: left;
    white-space: nowrap;
  }
  .offtarget-mini .result-table th:nth-child(1),
  .offtarget-mini .result-table td:nth-child(1) { min-width: 56px; }
  .offtarget-mini .result-table th:nth-child(2),
  .offtarget-mini .result-table td:nth-child(2) { min-width: 72px; }
  .offtarget-mini .result-table th:nth-child(3),
  .offtarget-mini .result-table td:nth-child(3) { min-width: 220px; }
  .offtarget-mini .result-table th:nth-child(4),
  .offtarget-mini .result-table td:nth-child(4) { min-width: 160px; }
  .offtarget-mini .result-table th:nth-child(5),
  .offtarget-mini .result-table td:nth-child(5) { min-width: 92px; }
  .offtarget-mini .result-table th:nth-child(6),
  .offtarget-mini .result-table td:nth-child(6) { min-width: 260px; }
  .offtarget-seq {
    font-family: ui-monospace, SFMono-Regular, Menlo, Monaco, Consolas, "Liberation Mono", "Courier New", monospace;
    font-size: 11px;
    letter-spacing: 0.1px;
  }
  .muted { color: var(--ui-muted); }
  @media (max-width: 1180px) {
    .layout { grid-template-columns: 1fr; }
    .grid-4 { grid-template-columns: repeat(2, minmax(0, 1fr)); }
    .advanced-oligo-grid { grid-template-columns: repeat(2, minmax(0, 1fr)); }
    .advanced-window-grid { grid-template-columns: repeat(2, minmax(0, 1fr)); }
  }
  @media (max-width: 900px) {
    .grid-2, .grid-3, .grid-4 { grid-template-columns: 1fr; }
    .advanced-oligo-grid { grid-template-columns: 1fr; }
    .advanced-window-grid { grid-template-columns: 1fr; }
    .gene-set-resolve-row { grid-template-columns: 1fr; }
    .gene-set-workspace { grid-template-columns: 1fr; }
    .legacy-search-toolbar { grid-template-columns: 1fr; }
    .kv-grid { grid-template-columns: 1fr; }
    .mini-bar { grid-template-columns: 1fr; }
    .insight-grid { grid-template-columns: 1fr; }
    .output-layout { grid-template-columns: 1fr; }
    .guide-head, .guide-row { grid-template-columns: 66px minmax(0, 1fr) 54px 58px 62px 52px; }
    .detail-pairs { grid-template-columns: 1fr; }
    .detail-pair-col + .detail-pair-col { border-left: none; border-top: 1px solid #dbe6f2; }
    .gtv-header { flex-direction: column; }
    .gtv-meta { margin-left: 0; }
  }
  #cas-type option[data-primary='1'] {
    font-weight: 700;
  }